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Veterans Affairs: Evidence-based Treatments for PTSD

Timothy Pena • Oct 14, 2023

Evidence-based therapies are among the most effective treatments for PTSD. 

Evidence-based therapies are among the most effective treatments for PTSD. They can include the following — which are in many cases available at a local VA medical center.


Cognitive Processing Therapy (CPT) helps Veterans to identify how traumatic experiences have affected their thinking, to evaluate those thoughts, and to change them. Through CPT, Veterans may develop more healthy and balanced beliefs about themselves others, and the world.


Prolonged Exposure (PE) helps Veterans to gradually approach and address traumatic memories, feelings, and situations. By confronting these challenges directly, Veterans may see PTSD symptoms begin to decrease.


Cognitive Behavioral Conjoint Therapy (CBCT) helps couples understand the effect of PTSD on relationships and can improve interpersonal communications. Veterans may also experience a change in thoughts and beliefs related to their PTSD and relationship challenges.


Eye Movement Desensitization and Reprocessing (EMDR) helps you process and make sense of your trauma. It involves calling the trauma to mind while paying attention to a back-and-forth movement or sound (like a finger waving side to side, a light, or a tone).

SSRIs and SNRIs


PTSD may be related to changes in the brain that are linked to our ability to manage stress. Compared with people who don’t have PTSD, people with PTSD appear to have different amounts of certain chemicals (called neurotransmitters) in the brain. SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin-norepinephrine reuptake inhibitors) are types of antidepressant medication that are believed to treat PTSD by putting these brain chemicals back in balance. They do not work as well as trauma-focused psychotherapy, but they can be effective.


Four SSRIs/SNRIs are recommended for PTSD:

  • Sertraline (Zoloft)
  • Paroxetine (Paxil)
  • Fluoxetine (Prozac)
  • Venlafaxine (Effexor)

(Medications have two names: a brand name — for example, Zoloft — and a generic name — for example, sertraline.)


To receive medications for PTSD, patients need to meet with a provider who can prescribe the medications. Many different types of providers, including your family health care provider and some nurses and physician assistants, can prescribe SSRIs and SNRIs for PTSD. You and your provider can work together to determine which medication may be the most effective for you. Learn more about SSRIs and SNRIs and how they compare with psychotherapies.


More info: https://www.mentalhealth.va.gov/ptsd/treatment.asp

Print this article: Veterans Affairs: PTSD Treatments

Timothy Pena initially traveled to NYC at the invitation of RIP Medical Debt founder and U.S. Navy Veteran Jerry Ashton to collaborate for his project, Veterans Mission Possible. Soon after arriving, Tim decided he would rather be homeless in NYC than commit suicide in Phoenix and spent five months in a shelter before obtaining his HUD/VASH voucher for supportive housing while detailing his journey from homeless to homeness with a series of articles called, 'Be the Story'. He has testified before the NYS Department of Veterans Affairs, is a member of the NYC Veterans Task Force and Military Veterans in Journalism, while founding The Forgotten Veteran non-profit. Email: Timothy Pena

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